25 Feb Understanding Nano Emulsified CBD
Q. How is this made? Emulsification through frequency
- A. We are performing a very common technique used in many industries called emulsification. Emulsification is the process of solubilizing either water into oil or in our case oil into water. Both processes are similar and simply refer to the major component of the solution; oil in the first case and water in our case. The idea is to capture your oil (containing CBD) in small surfactant bubbles. If these bubbles are small enough then they will remain suspended in the water and be stable for a period of time depending on the size. The smaller the size of these bubbles the more stable the solution will be over time. “Nano” or “Nano-emulsified” solutions are simply solutions with very small bubbles suspended in water; 100 nanometer diameter = 0.00000001 meter diameter. For comparison, the hemoglobin protein is approximately 5 nanometers in diameter. So, we are making bubbles that are within the same size range as proteins in the human body.
Q. So, why are we doing this? Bioavailability
- A. The answer is to produce a delivery mechanism with greater bioavailability to the user. Oil is not easily absorbed by the human body since we are primarily composed of water. The body does however have a natural mechanism for breaking apart oil and absorbing it into the blood stream. The problem is that much of the oil passes through the digestive system before the body can fully absorb the oil. Interestingly, the mechanism that the body uses is like emulsification. The body will pull the oil apart using bile and capture it inside a small bubble-like structure composed of bile salts. These small bubbles have greater surface area aiding the enzymatic activity of pancreatic lipase which further breaks the bubbles down allowing easy absorption into the bloodstream. When we capture drug molecules inside nanometer sized bubbles the body does not need to act on the bubbles to achieve absorption. The drug is then more readily absorbed by the body.
Q. Benefits: Why is this beneficial?
- A. The benefit then should be obvious. Since nano-emulsified drug molecules are absorbed more readily then users can use a lower dosage of CBD to achieve the desired therapeutic effect.
Q. Aerosource H Product: Why is ours superior?
- A. The small the size of the emulsified drug bubble the greater the absorption. The nano product created from my formulation is measuring in the 80-nanometer range. This is very small compared to what we have observed on the market.
Q. How do we explain the concentration?
We can express concentration several different ways. Let me try to explain the two that you are considering.
Milligrams of solid whatever in each 1 milliliter of fluid. Think of something like milk. If we take 1mL of milk (5 milliliters is about 1 teaspoon) we can express the amount of protein dissolved in the milk in terms of milligrams. There are about 34 milligrams of protein in 1 milliliter of 1% milk. If we dried the 1 milliliter of milk and we separated everything else out we should be able to weigh 34 milligrams of protein. We can dissolve solids into liquids by weighing them out and dissolving. If we weigh the solid and measure the volume of the liquid we are using then we can express the concentration in mg/mL.
Instead of using milliliters we can use mass; milligrams, grams, kilograms, etc. So, in this case we look at how many milligrams of stuff is in 1 milligram of total stuff. In the milk example we can express the amount of protein (mass) per mass unit of the total stuff. If we weigh 1 gram of milk out we can ask ourselves, “How many grams of protein are in the 1 gram of milk?” Now, because milk is mostly water which has a density of 1 gram/mL then the answer is going to be the same with different units. We will get 34 milligrams per 1 milliliter or 34 milligrams of protein per 1000 milligrams of solution (34 milligrams/1 gram).
We can do the same with CBD in our solutions. We control how much we put into the solution. That is important to remember. We are not measuring how much is in the solution. We are preparing the solution to be exactly what we want. So, if we want to prepare a 1% solution of CBD nano, we need to dissolve enough CBD to be 1% of the final solution. If we are preparing 1 liter of solution which equals 1000 milliliters then we need 10 gram of CBD dissolved in 999 grams of other stuff. Right? 1% of 1000 grams is 10 grams (0.01 * 1000). Why 10 grams? Since our solutions are almost entirely water (~80%), then the density of our solution is essentially equal to 1 gram per milliliter. This means that we have 10 grams of CBD per 1000 milliliters or grams of solution = 10,000 milligrams per 1,000,000 milligrams of total solution (1000mg/g) = 0.01 mg/mg concentration.
Therefore a 1% solution is equal to 0.01 mg/mg concentration of CBD or 10 mg/mL. For each liter of solution that we want we would weigh out 10 grams, dissolve, and emulsify the solution.